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KMID : 1130320110540040157
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Korean Journal of Pediatrics
2011 Volume.54 No. 4 p.157 ~ p.162
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Alteration of CD4+CD25+Foxp3+ T cell level in Kawasaki disease
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Sohn Su-Ye
Song Young-Wooh
Yeo Yun-Ku
Kim Yun-Kyung
Jang Gi-Young
Woo Chan-Wook
Lee Jung-Hwa
Lee Kwang-Chul
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Abstract
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Purpose : Exaggerated pro-inflammatory reactions during the acute phase of Kawasaki disease (KD) suggest the role of immune dysregulation in the pathogenesis of KD. We investigated the profiles of T regulatory cells and their correlation with the clinical course of KD.
Methods : Peripheral blood mononuclear cells were collected from 17 KD patients during acute febrile and subacute afebrile phases. T cells expressing CD4, CD25, and Foxp3 were analyzed using flow cytometry, and the results were correlated with the clinical course of KD.
Results : The percentage of circulating CD4+CD25highFoxp3+ T cells among CD4+ T cells was significantly higher during the subacute afebrile phase than during the acute febrile phase (1.10%±1.22% vs. 0.55%±0.53%, P=0.049). Although levels of CD4+CD25lowFoxp3+ T cells and CD4+CD25?Foxp3+ T cells were only slightly altered, the percentage of CD4+CD25+Foxp3? T cells among CD4+ T cells was significantly lower during the subacute afebrile phase than during the acute febrile phase (2.96%±1.95% vs. 5.64%±5.69%, P=0.036). Consequently, the ratio of CD25highFoxp3+ T cells to CD25+Foxp3? T cells was higher during the subacute afebrile phase than during the acute febrile phase (0.45%±0.57% vs. 0.13%±0.13%, P=0.038).
Conclusion : Decreased CD4+CD25highFoxp3+ T cells and/or an imbalanced ratio of CD4+CD25highFoxp3+ T cells to CD4+CD25+ Foxp3? T cells might play a role in KD development. Considering that all KD patients were treated with intravenous immunoglobulin (IVIG), recovery of CD4+CD25highFoxp3+ T cells during the subacute afebrile phase could be a mechanism of IVIG.
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KEYWORD
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Kawasaki disease, Regulatory T cell, CD25+, Foxp3+
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